Synonyms: analogue 4f [Brown et al., 1991] [1] | BRL44154
Compound class:
Synthetic organic
Comment: Strictly this is the parent molecule of BRL-44154 which referes to the sodium salt. BRL-44154 is a penicillin class antibacterial that was developed by SmithKline Beecham [2]. It has high stability to β-lactamases.
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References |
1. Brown P, Calvert SH, Chapman PCA, Cosham SC, Eglington AJ, Elliot RL, Harris MA, Hinks JD, Lowther D, Merrikin DJ et al..
p- Lactamase-Stable Penicillins. Synthesis and Structure-Activity Relationships of (Z)-Alkyloxyimino Penicillins; Selection of BRL 441 54. Accessed on 12/06/2020. Modified on 12/06/2020. pubs.rsc.org, https://pubs.rsc.org/en/content/articlepdf/1991/p1/p19910000881 |
2. Mizen L, Berry V, Woodnutt G. (1995)
The influence of uptake from the gastrointestinal tract and first-pass effect on oral bioavailability of (Z)-alkyloxyimino penicillins. J Pharm Pharmacol, 47 (9): 725-30. [PMID:8583383] |