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MDL12330A (parent)   Click here for help

GtoPdb Ligand ID: 11357

Synonyms: MDL 12330A | MDL-12330A | RMI 12330A | RMI12330A
Compound class: Synthetic organic
Comment: MDL12330A is a non-selective adenylyl cyclase inhibitor [2]. It also modulates cyclic GMP metabolism and cyclic AMP phosphodiesterase activities [1,3]. It used as an experimental tool, most commonly as the hydrochloride salt.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 24.39
Molecular weight 340.29
XLogP 6.93
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C1CCCCCN=C(CCCCC1)N[C@H]1CCC[C@H]1c1ccccc1
Isomeric SMILES C1CCCCCN=C(CCCCC1)N[C@H]1CCC[C@H]1c1ccccc1
InChI InChI=1S/C23H36N2/c1-2-4-6-11-18-23(24-19-12-7-5-3-1)25-22-17-13-16-21(22)20-14-9-8-10-15-20/h8-10,14-15,21-22H,1-7,11-13,16-19H2,(H,24,25)/t21-,22-/m0/s1
InChI Key RTRIXVOSRYRSBP-VXKWHMMOSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. Biondi C, Campi AL, Pareschi MC, Portolan A, Ferretti ME. (1990)
RMI 12330A, an inhibitor of adenylate cyclase and cyclic AMP-phosphodiesterase activities in the segmental ganglia of the leech Hirudo medicinalis.
Neurosci Lett, 113 (3): 322-7. [PMID:2166256]
2. Guellaen G, Mahu JL, Mavier P, Berthelot P, Hanoune J. (1977)
RMI 12330 A, an inhibitor of adenylate cyclase in rat liver.
Biochim Biophys Acta, 484 (2): 465-75. [PMID:911855]
3. Hunt NH, Evans T. (1980)
RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations.
Biochim Biophys Acta, 613 (2): 499-506. [PMID:6256001]