Synonyms: MDL 12330A | MDL-12330A | RMI 12330A | RMI12330A
Compound class:
Synthetic organic
Comment: MDL12330A is a non-selective adenylyl cyclase inhibitor [2]. It also modulates cyclic GMP metabolism and cyclic AMP phosphodiesterase activities [1,3]. It used as an experimental tool, most commonly as the hydrochloride salt.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Biondi C, Campi AL, Pareschi MC, Portolan A, Ferretti ME. (1990)
RMI 12330A, an inhibitor of adenylate cyclase and cyclic AMP-phosphodiesterase activities in the segmental ganglia of the leech Hirudo medicinalis. Neurosci Lett, 113 (3): 322-7. [PMID:2166256] |
2. Guellaen G, Mahu JL, Mavier P, Berthelot P, Hanoune J. (1977)
RMI 12330 A, an inhibitor of adenylate cyclase in rat liver. Biochim Biophys Acta, 484 (2): 465-75. [PMID:911855] |
3. Hunt NH, Evans T. (1980)
RMI 12330A, an inhibitor of cyclic nucleotide phosphodiesterases and adenylate cyclase in kidney preparations. Biochim Biophys Acta, 613 (2): 499-506. [PMID:6256001] |