Synonyms: compound 16 [PMID: 29701957]
Compound class:
Synthetic organic
Comment: VU0486846 is a positive allosteric modulator of M1 muscarinic acetylcholine receptors [1]. Activation of M1 receptors by such compounds is proposed to improve cognition in conditions that are associated with cholinergic deficit such as schizophrenia, and Alzheimer's and Parkinson's diseases. VU0486846 exhibits very weak M1 agonist activity in vitro and is inactive in the prefrontal cortex and does not induce cholinergic adverse effects in vivo.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
(2R)-N-[(1S,2S)-2-hydroxycyclohexyl]-4-[(4-pyrazol-1-ylphenyl)methyl]-2,3-dihydro-1,4-benzoxazine-2-carboxamide |
Synonyms |
compound 16 [PMID: 29701957] |
Database Links | |
Specialist databases | |
GPCRdb Ligand | VU0486846 |
Other databases | |
BindingDB Ligand | 50273248 |
CAS Registry No. | 1788055-11-7 (source: PubChem) |
GtoPdb PubChem SID | 479821096 |
PubChem CID | 118124117 |
Search Google for chemical match using the InChIKey | LZCHTDQRMCSDSE-ODGPQVTHSA-N |
Search Google for chemicals with the same backbone | LZCHTDQRMCSDSE |
UniChem Compound Search for chemical match using the InChIKey | LZCHTDQRMCSDSE-ODGPQVTHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | LZCHTDQRMCSDSE-ODGPQVTHSA-N |