cinoxacin   Click here for help

GtoPdb Ligand ID: 12401

Synonyms: Cinobac® | Lilly 64716
Approved drug
cinoxacin is an approved drug (UK (1979), FDA (1980))
Compound class: Synthetic organic
Comment: Cinoxacin is a quinolone antibacterial compound with activity against Gram-negative bacteria [2].

cinoxacin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 90.65
Molecular weight 262.06
XLogP 0.57
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCn1nc(C(=O)O)c(=O)c2c1cc1OCOc1c2
Isomeric SMILES CCn1c2cc3c(cc2c(=O)c(n1)C(=O)O)OCO3
InChI InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)
InChI Key VDUWPHTZYNWKRN-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. UK (1979)  |  FDA (1980)
Withdrawn drug? Yes
IUPAC Name Click here for help
1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
3513 cinoxacin
Synonyms Click here for help
Cinobac® | Lilly 64716
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Cinoxacin
Other databases
CAS Registry No. 28657-80-9 (source: Scifinder)
ChEBI CHEBI:3716
ChEMBL Ligand CHEMBL1208
DrugBank Ligand DB00827
DrugCentral Ligand 657
GtoPdb PubChem SID 479821192
PubChem CID 2762
Search Google for chemical match using the InChIKey VDUWPHTZYNWKRN-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VDUWPHTZYNWKRN
Search PubMed clinical trials cinoxacin
Search PubMed titles cinoxacin
Search PubMed titles/abstracts cinoxacin
UniChem Compound Search for chemical match using the InChIKey VDUWPHTZYNWKRN-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VDUWPHTZYNWKRN-UHFFFAOYSA-N

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MedChemExpress
Cinoxacin (links to external site)
Cat. No. HY-B1085