cinoxacin   Click here for help

GtoPdb Ligand ID: 12401

Synonyms: Cinobac® | Lilly 64716
Approved drug
cinoxacin is an approved drug (UK (1979), FDA (1980))
Compound class: Synthetic organic
Comment: Cinoxacin is a quinolone antibacterial compound with activity against Gram-negative bacteria [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 90.65
Molecular weight 262.06
XLogP 0.57
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCn1nc(C(=O)O)c(=O)c2c1cc1OCOc1c2
Isomeric SMILES CCn1c2cc3c(cc2c(=O)c(n1)C(=O)O)OCO3
InChI InChI=1S/C12H10N2O5/c1-2-14-7-4-9-8(18-5-19-9)3-6(7)11(15)10(13-14)12(16)17/h3-4H,2,5H2,1H3,(H,16,17)
InChI Key VDUWPHTZYNWKRN-UHFFFAOYSA-N
No information available.
Summary of Clinical Use Click here for help
Cinoxacin was withdrawn from use in European jurisdictions in 2018 following the EMA's recommendation on the use of quinolone antibacterials [1]. An oral preparation was marketed by Eli Lilly in the US (under the trade name Cinobac®) for the treatment of urinary tract infections but has been discontinued.