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zuranolone   Click here for help

GtoPdb Ligand ID: 12858

Synonyms: compound 3 [PMID: 28753313] | SAGE-217 | SAGE217 | Zurzuvae®
Approved drug
zuranolone is an approved drug (FDA (2023))
Compound class: Synthetic organic
Comment: Zuranolone (SAGE-217) is a novel, rapid-acting, oral antipsychotic [1]. It is a neuroactive steroid that acts as a positive allosteric modulator of synaptic and extrasynaptic GABAA receptors [2,4].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 3
Topological polar surface area 76.69
Molecular weight 409.57
XLogP 5.61
No. Lipinski's rules broken 1

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES C[C@]1(CC[C@H]2[C@H](CC[C@@H]3[C@@H]2CC[C@@]4(C)[C@H]3CC[C@@H]4C(=O)CN5C=C(C#N)C=N5)C1)O
Isomeric SMILES C[C@]1(CC[C@H]2[C@@H](C1)CC[C@@H]3[C@@H]2CC[C@]4([C@H]3CC[C@@H]4C(=O)CN5C=C(C=N5)C#N)C)O
InChI InChI=1S/C25H35N3O2/c1-24(30)9-7-18-17(11-24)3-4-20-19(18)8-10-25(2)21(20)5-6-22(25)23(29)15-28-14-16(12-26)13-27-28/h13-14,17-22,30H,3-11,15H2,1-2H3/t17-,18+,19-,20-,21+,22-,24-,25+/m1/s1
InChI Key HARRKNSQXBRBGZ-GVKWWOCJSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (2023)
IUPAC Name Click here for help
1-[2-[(3R,5R,8R,9R,10S,13S,14S,17S)-3-hydroxy-3,13-dimethyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl]pyrazole-4-carbonitrile
International Nonproprietary Names Click here for help
INN number INN
10896 zuranolone
Synonyms Click here for help
compound 3 [PMID: 28753313] | SAGE-217 | SAGE217 | Zurzuvae®
Database Links Click here for help
BindingDB Ligand 50258216
CAS Registry No. 1632051-40-1 (source: WHO INN record)
ChEMBL Ligand CHEMBL4105630
GtoPdb PubChem SID 483123406
PubChem CID 86294073
Search Google for chemical match using the InChIKey HARRKNSQXBRBGZ-GVKWWOCJSA-N
Search Google for chemicals with the same backbone HARRKNSQXBRBGZ
Search PubMed clinical trials zuranolone
Search PubMed titles zuranolone
Search PubMed titles/abstracts zuranolone
UniChem Compound Search for chemical match using the InChIKey HARRKNSQXBRBGZ-GVKWWOCJSA-N
UniChem Connectivity Search for chemical match using the InChIKey HARRKNSQXBRBGZ-GVKWWOCJSA-N