Synonyms: compound 3 [PMID: 28753313] | SAGE-217 | SAGE217 | Zurzuvae®
zuranolone is an approved drug (FDA (2023))
Compound class:
Synthetic organic
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References |
1. Carvalho T. (2023)
New depression drug zuranolone one step closer to FDA ruling. Nat Med, 29 (5): 1032-1033. [PMID:37041352] |
2. Cutler AJ, Mattingly GW, Maletic V. (2023)
Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder. Transl Psychiatry, 13 (1): 228. [PMID:37365161] |
3. Deligiannidis KM, Meltzer-Brody S, Maximos B, Peeper EQ, Freeman M, Lasser R, Bullock A, Kotecha M, Li S, Forrestal F et al.. (2023)
Zuranolone for the Treatment of Postpartum Depression. Am J Psychiatry, 180 (9): 668-675. [PMID:37491938] |
4. Martinez Botella G, Salituro FG, Harrison BL, Beresis RT, Bai Z, Blanco MJ, Belfort GM, Dai J, Loya CM, Ackley MA et al.. (2017)
Neuroactive Steroids. 2. 3α-Hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217): A Clinical Next Generation Neuroactive Steroid Positive Allosteric Modulator of the (γ-Aminobutyric Acid)A Receptor. J Med Chem, 60 (18): 7810-7819. [PMID:28753313] |