prulifloxacin   Click here for help

GtoPdb Ligand ID: 12860

Synonyms: NM441
Approved drug
prulifloxacin is an approved drug (EMA, Japan)
Compound class: Synthetic organic
Comment: Prulifloxacin is a fluoroquinolone antibacterial compound and the prodrug ulifloxacin [5].

prulifloxacin is commercially available from our sponsors

2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 124.92
Molecular weight 461.47
XLogP 2.5
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC1=C(CN2CCN(CC2)C3=CC4=C(C=C3F)C(=O)C(=C5N4C(C)S5)C(=O)O)OC(=O)O1
Isomeric SMILES CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCN(CC4)CC5=C(OC(=O)O5)C
InChI InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)
InChI Key PWNMXPDKBYZCOO-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. EMA (0)  |  Japan (0)
IUPAC Name Click here for help
6-fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]piperazin-1-yl]-4-oxo-1H-[1,3]thiazeto[3,2-a]quinoline-3-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
7249 prulifloxacin
Synonyms Click here for help
NM441
Database Links Click here for help
Specialist databases
Antibiotic DB Antibiotic DB Database logo Prulifloxacin
Other databases
CAS Registry No. 123447-62-1 (source: Scifinder)
ChEBI CHEBI:32071
ChEMBL Ligand CHEMBL422648
DrugBank Ligand DB11892
DrugCentral Ligand 2325
GtoPdb PubChem SID 485205981
PubChem CID 65947
Search Google for chemical match using the InChIKey PWNMXPDKBYZCOO-UHFFFAOYSA-N
Search Google for chemicals with the same backbone PWNMXPDKBYZCOO
Search PubMed clinical trials prulifloxacin
Search PubMed titles prulifloxacin
Search PubMed titles/abstracts prulifloxacin
UniChem Compound Search for chemical match using the InChIKey PWNMXPDKBYZCOO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey PWNMXPDKBYZCOO-UHFFFAOYSA-N
Wikipedia Prulifloxacin

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MedChemExpress
Prulifloxacin (links to external site)
Cat. No. HY-B0024