prulifloxacin   Click here for help

GtoPdb Ligand ID: 12860

Synonyms: NM441
Approved drug
prulifloxacin is an approved drug (EMA, Japan)
Compound class: Synthetic organic
Comment: Prulifloxacin is a fluoroquinolone antibacterial compound and the prodrug ulifloxacin [5].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 9
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 124.92
Molecular weight 461.47
XLogP 2.5
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CC1=C(CN2CCN(CC2)C3=CC4=C(C=C3F)C(=O)C(=C5N4C(C)S5)C(=O)O)OC(=O)O1
Isomeric SMILES CC1N2C3=CC(=C(C=C3C(=O)C(=C2S1)C(=O)O)F)N4CCN(CC4)CC5=C(OC(=O)O5)C
InChI InChI=1S/C21H20FN3O6S/c1-10-16(31-21(29)30-10)9-23-3-5-24(6-4-23)15-8-14-12(7-13(15)22)18(26)17(20(27)28)19-25(14)11(2)32-19/h7-8,11H,3-6,9H2,1-2H3,(H,27,28)
InChI Key PWNMXPDKBYZCOO-UHFFFAOYSA-N
References
1. European Medicines Agency. 
Quinolone- and fluoroquinolone-containing medicinal products.
Accessed on 16/03/2023. Modified on 16/03/2023. https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products
2. Fritsche TR, Biedenbach DJ, Jones RN. (2009)
Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea.
Antimicrob Agents Chemother, 53 (3): 1221-4. [PMID:19114678]
3. Giannarini G, Tascini C, Selli C. (2009)
Prulifloxacin: clinical studies of a broad-spectrum quinolone agent.
Future Microbiol, 4 (1): 13-24. [PMID:19207096]
4. Keam SJ, Perry CM. (2004)
Prulifloxacin.
Drugs, 64 (19): 2221-34; discussion 2235-6. [PMID:15456336]
5. Ozaki M, Matsuda M, Tomii Y, Kimura K, Segawa J, Kitano M, Kise M, Shibata K, Otsuki M, Nishino T. (1991)
In vivo evaluation of NM441, a new thiazeto-quinoline derivative.
Antimicrob Agents Chemother, 35 (12): 2496-9. [PMID:1667252]