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pridopidine   Click here for help

GtoPdb Ligand ID: 13833

Synonyms: ACR-16 | ACR16 | compound 12b [PMID: 20155917]
Compound class: Synthetic organic
Comment: Pridopidine (ACR16) is an orally bioavailable small molecule investigational drug that was discovered to stabilise dopaminergic signalling [3]. It has activity as a Sigma-1 receptor (SIGMAR1) agonist [4].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 4
Topological polar surface area 45.76
Molecular weight 281.42
XLogP 1.52
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCCN1CCC(CC1)C2=CC=CC(=C2)S(=O)(=O)C
Isomeric SMILES CCCN1CCC(CC1)C2=CC(=CC=C2)S(=O)(=O)C
InChI InChI=1S/C15H23NO2S/c1-3-9-16-10-7-13(8-11-16)14-5-4-6-15(12-14)19(2,17)18/h4-6,12-13H,3,7-11H2,1-2H3
InChI Key YGKUEOZJFIXDGI-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
References
1. de Yebenes JG, Landwehrmeyer B, Squitieri F, Reilmann R, Rosser A, Barker RA, Saft C, Magnet MK, Sword A, Rembratt A et al.. (2011)
Pridopidine for the treatment of motor function in patients with Huntington's disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial.
Lancet Neurol, 10 (12): 1049-57. [PMID:22071279]
2. McGarry A, Kieburtz K, Abler V, Grachev ID, Gandhi S, Auinger P, Papapetropoulos S, Hayden M. (2017)
Safety and Exploratory Efficacy at 36 Months in Open-HART, an Open-Label Extension Study of Pridopidine in Huntington's Disease.
J Huntingtons Dis, 6 (3): 189-199. [PMID:28826192]
3. Pettersson F, Pontén H, Waters N, Waters S, Sonesson C. (2010)
Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).
J Med Chem, 53 (6): 2510-20. [PMID:20155917]
4. Waters S, Tedroff J, Ponten H, Klamer D, Sonesson C, Waters N. (2018)
Pridopidine: Overview of Pharmacology and Rationale for its Use in Huntington's Disease.
J Huntingtons Dis, 7 (1): 1-16. [PMID:29480206]
5. Writing Committee for the HEALEY ALS Platform Trial, Shefner JM, Oskarsson B, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J et al.. (2025)
Pridopidine in Amyotrophic Lateral Sclerosis: The HEALEY ALS Platform Trial.
JAMA, [Epub ahead of print]. [PMID:40067755]
6. Ye N, Qin W, Tian S, Xu Q, Wold EA, Zhou J, Zhen XC. (2020)
Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases.
J Med Chem, 63 (24): 15187-15217. [PMID:33111525]