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LTV17   Click here for help

GtoPdb Ligand ID: 14299

Synonyms: compound 17 [PMID: 24694215]
Compound class: Synthetic organic
Comment: LTV17 is a derivative of the naturally occurring antibacterial lactivicin. It has been designed to have increased potency against Gram-negative bacteria by modification of the lactivicin core scaffold with a phthalimide-conjugated siderophore [2].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 16
Hydrogen bond donors 6
Rotatable bonds 10
Topological polar surface area 322.65
Molecular weight 662.54
XLogP -3.83
No. Lipinski's rules broken 3

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2CON(C2=O)C3(C[C@@H](C(=O)O3)N4C(=O)C5=C(C=C(C(=C5)O)O)C4=O)C(=O)O
Isomeric SMILES CC(C)(C(=O)O)O/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2CON(C2=O)C3(C[C@@H](C(=O)O3)N4C(=O)C5=CC(=C(C=C5C4=O)O)O)C(=O)O
InChI InChI=1S/C25H22N6O14S/c1-24(2,21(39)40)45-29-15(11-7-46-23(26)28-11)16(34)27-10-6-43-31(19(10)37)25(22(41)42)5-12(20(38)44-25)30-17(35)8-3-13(32)14(33)4-9(8)18(30)36/h3-4,7,10,12,32-33H,5-6H2,1-2H3,(H2,26,28)(H,27,34)(H,39,40)(H,41,42)/b29-15-/t10-,12-,25?/m0/s1
InChI Key JIGNDUNBKKQBKB-OIANMIDYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Bioactivity Comments
LTV17 exhibits improved activity compared to aztreonam against Gram-negative pathogenic bacteria, including against P. aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli [2]. It is also active against Stenotrophomonas maltophilia (MIC ≤, 62.5 ng/ml), a Gram-negative species that forms biofilms and that can be resistant to antibacterial drugs [1]. In addition, LTV17 exhibits resistance to inactivation by β-lactamase enzymes [2].
LTV17 inhibits Pseudomonas aeruginosa PAO1 penicillin-binding protein 1A (PBP1a) with an IC50 of 30 nM and PBP3 with an IC50 of 46 nM [2].