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golimumab   Click here for help

GtoPdb Ligand ID: 6776

Synonyms: CNTO-148 | CNTO148 | Simponi®
Approved drug Immunopharmacology Ligand
golimumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: TNFα inhibitor.

Biosimilars:
NameTrade nameCompanyApprovalIndications
biosimilar golimumab; AVT05Gobivaz®Alvotech/Advanz PharmaEMA (2025)Biosimilar to Simponi®
biosimilar golimumab; BAT2506Gotenfia®Stada ArzneimittelEMA (2026)Biosimilar to Simponi®
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View more information in the IUPHAR Pharmacology Education Project: golimumab

Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
tumour necrosis factor shed form Primary target of this compound Hs Antibody Binding 10.7 pIC50 - 2
⤷ pIC50 10.7 (IC50 1.8x10-11 M) [2]
Description: Affinity for soluble TNFα measured by surface plasmon resonance