golimumab   Click here for help

GtoPdb Ligand ID: 6776

Synonyms: CNTO-148 | CNTO148 | Simponi®
Approved drug Immunopharmacology Ligand
golimumab is an approved drug (FDA (2009), EMA (2009))
Compound class: Antibody
Comment: TNFα inhibitor.
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Summary of Clinical Use Click here for help
Used in adults with various inflammatory conditions [3] e.g. moderate to severe active rheumatoid arthritis [1], active psoriatic arthritis, active ankylosing spondylitis and moderate to severe ulcerative colitis.
Mechanism Of Action and Pharmacodynamic Effects Click here for help
Anti-TNFα monoclonal antibody which binds and neutralises soluble and membrane human TNFα, a pro-inflammatory cytokine associated with chronic inflammation.
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