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lorvotuzumab mertansine   Click here for help

GtoPdb Ligand ID: 7431

Synonyms: BB-10901 | IMGN901
Compound class: Antibody
Comment: Lorvotuzumab mertansine is an antibody-drug conjugate (ADC) combining an anti-NCAM1 (CD56) monoclonal antibody with the maytansinoid DM1 (PubChem CID 71301226) tubulin inhibitor [2].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-db record. Patent US5639641 [4] describes the resurfacing of murine anti-CD56 monoclonal antibody N901, to improve its therapeutic efficacy in preparation for use as a human drug. A protein BLAST search matches the variable region of the light chain of lorvotuzumab, with sequence 36 from the patent, sequence 36 being a CDR grafted version of N901. No affinity data for the interaction between the preferred engineered antibody and the molecular target is provided in the patent.
Classification Click here for help
Compound class Antibody
International Nonproprietary Names Click here for help
INN number INN
9299 lorvotuzumab mertansine
Synonyms Click here for help
BB-10901 | IMGN901
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 58
Other databases
GtoPdb PubChem SID 178104003
PubChem SID 178104003
Search PubMed clinical trials lorvotuzumab mertansine
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Wikipedia Lorvotuzumab mertansine