lorvotuzumab mertansine

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Ligands
lorvotuzumab mertansine

GtoPdb Ligand ID: 7431

Synonyms: BB-10901 | IMGN901

Comment: Lorvotuzumab mertansine is an antibody-drug conjugate (ADC) combining an anti-NCAM1 (CD56) monoclonal antibody with the maytansinoid DM1 (PubChem CID 71301226) tubulin inhibitor [2].
Annotated peptide sequences for this antibody are available from its IMGT/mAb-db record. Patent US5639641 [4] describes the resurfacing of murine anti-CD56 monoclonal antibody N901, to improve its therapeutic efficacy in preparation for use as a human drug. A protein BLAST search matches the variable region of the light chain of lorvotuzumab, with sequence 36 from the patent, sequence 36 being a CDR grafted version of N901. No affinity data for the interaction between the preferred engineered antibody and the molecular target is provided in the patent.

Bioactivity Comments
We have been unable to find publicly available data providing a binding affinity for this antibody at its molecular target or for the potency of the maytansinoid tubulin inhibitor.

Bioactivity Comments

We have been unable to find publicly available data providing a binding affinity for this antibody at its molecular target or for the potency of the maytansinoid tubulin inhibitor.