Compound class:
Synthetic organic
Comment: The chemical structure shown here was drawn from [1]. LUF6200 acts as an inhibitory allosteric modulator of the human ether-à-go-go (hERG) K+ channel, with respect to astemizole and dofetilide, but displays positive co-operativity with K+ ions [1].
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References |
1. Yu Z, Klaasse E, Heitman LH, Ijzerman AP. (2014)
Allosteric modulators of the hERG K(+) channel: radioligand binding assays reveal allosteric characteristics of dofetilide analogs. Toxicol Appl Pharmacol, 274 (1): 78-86. [PMID:24200993] |