Synonyms: Org 27569
Compound class:
Synthetic organic
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Org27569 is a positive allosteric modulator of CP55940 (an orthosteric agonist) affinity at the CB1 receptor, but negatively modulates CP55940 efficacy at the same receptor [3]. Org27569 traps the receptor in a distinct agonist-bound, but nonsignaling conformational state [1]. |
Selectivity at GPCRs | ||||||||||||||||||||||||||||||||||
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