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LY2928057   Click here for help

GtoPdb Ligand ID: 8416

Compound class: Antibody
Comment: LY2928057 is an investigational anti-ferroportin monoclonal being developed as a treatment for anemia. A search of patents reveals WO2010065496 A1 as Eli Lilly's application covering the development and use of anti-ferroportin 1 monoclonal antibodies [1]. The HGNC approved gene symbol for ferroportin 1 is SLC40A1.
Bioactivity Comments
In WO2010065496 the only humanised clone accompanied with a Kd for ferropotin binding is human 3D8. The Kd value is 3.37nM [1]. This clone also inhibits ferrorortin internalisation and degradation with an IC50 value of 13.7nM. We have tagged SLC40A1 as the primary target of this antibody based on the patent contents.
Selectivity at transporters
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Ferroportin Primary target of this compound Hs Antibody Binding - - - 1
⤷ [1]