Compound class:
Synthetic organic
Comment: Cl-amidine is an inhihbitor of protein arginine deiminases (PADIs). Although reported to preferentially inhibit PADI1, isozyme selectivity is poor [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
The authors provide inhibition values as rate constants (kinact/KI) for Cl-amidine as a measure of inhibitory activity. The rate constants for PADI1 and PADI2 are 4.55x103 M-1 min-1 and 5.2x102 M-1 min-1 respectively. NB click on the down arrow at the end of the row in the table below to reveal the rate constant. |
Selectivity at enzymes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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