Ligand id: 10000

Name: ASN002

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 134.06
Molecular weight 460.23
XLogP 2.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
To date no bioactivity data for ASN002 has been disclosed in peer reviewed literature (June 2018), although preclinical and early clinical data has been presented in meeting abstracts (see references 118-120 in He and Guttman-Yassky (2018) [1].
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
spleen associated tyrosine kinase Hs Inhibitor Inhibition >8.0 pIC50 - 2
pIC50 >8.0 (IC50 <1x10-8 M) [2]
Janus kinase 2 Hs Inhibitor Inhibition >7.3 pIC50 - 2
pIC50 >7.3 (IC50 <5x10-8 M) [2]