cemiplimab   Click here for help

GtoPdb Ligand ID: 10090

Synonyms: cemiplimab-rwlc | Libtayo® | REGN-2810 | REGN2810 | SAR-439684 | SAR439684
Approved drug Immunopharmacology Ligand
cemiplimab is an approved drug (FDA (2018), EMA (2019))
Compound class: Antibody
Comment: Cemiplimab (REGN2810) is a fully human anti-PD-1 immuno-oncology biological therapeutic that was developed by Regeneron Pharmaceuticals [1-2]. This antibody was produced using Regeneron's genetically engineered VelocImmune® mice which have humanized immunoglobulin gene loci and produce human:mouse hybrid antibodies that can rapidly be converted to fully human antibodies [4].
Full peptide sequence and disulphide bond information is available from the IMGT/mAb-DB entry for this antibody.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Bioactivity Comments
Cemiplimab does not bind mouse PD-1 in vitro or in vivo, or rat PD-1 in vitro [1]. The antibody blocks human PD-1/PD-L1 interaction with an IC50 <1nM in an ELISA [1].
Selectivity at other protein targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
programmed cell death 1 (CD279) Primary target of this compound Hs Antibody Binding 8.2 – 9.2 pKd - 1
⤷ pKd 9.2 (Kd 6.28x10-10 M) [1]
Description: Immobilised antibody binding to mobile phase dimeric human PD-1 in a Biacore chip assay.
pKd 8.2 (Kd 6.11x10-9 M) [1]
Description: Immobilised antibody binding to mobile phase monomeric human PD-1 in a Biacore chip assay.
programmed cell death 1 (CD279) Monkey Antibody Binding 8.1 – 9.3 pKd - 1
⤷ pKd 9.3 (Kd 5.2x10-10 M) [1]
Description: Immobilised antibody binding to mobile phase dimeric monkey PD-1 in a Biacore chip assay.
pKd 8.1 (Kd 7.43x10-9 M) [1]
Description: Immobilised antibody binding to mobile phase monomeric monkey PD-1 in a Biacore chip assay.