Jedi2   Click here for help

GtoPdb Ligand ID: 10111

Synonyms: Jedi 2 | Jedi-2
Compound class: Synthetic organic
Comment: Jedi2 is reported as an activator of the mechanosensitive Piezo1 ion channel [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 78.68
Molecular weight 208.02
XLogP 1.49
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)c1cc(oc1C)c1cccs1
Isomeric SMILES OC(=O)c1cc(oc1C)c1cccs1
InChI InChI=1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12)
Bioactivity Comments
Jedi2 induces Ca2+ influx into HEK293T cells expressing mouse Piezo1 channels, but does not elicit a response in Piezo2-expressing cells [1].
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Piezo1 Primary target of this compound Mm Activator Activation 3.8 pEC50 - 1
pEC50 3.8 (EC50 1.58x10-4 M) [1]
Description: Measuring calcium flux (GCAMP6s fluorescence) in mPiezo1-transfected HEK293T cells.