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Compound class: Synthetic organic
Comment: Compound 1u is the hit compound identified from a SAR study of peptoid-based histone deacetylase (HDAC) inhibitors for use as antimalarial agents .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|The interaction table below provides data from whole cell assays, with compound 1u demonstrating potent in vitro activity against the asexual blood stage of both drug-sensitive and drug-resistant strains of P. falciparum and against exoerythrocytic forms of P. berghei . The molecule also demonstrates activity against P. falciparum clinical isolates .
Note: PfHDAC1 has been tagged as the target for this ligand for data retrieval purposes, pending confirmation of the primary molecular target.
|Whole organism assay data|
|Key to terms and symbols||Click on species/strain names for details||Click column headers to sort|