Compound class:
Natural product
Comment: Tonantzitlolone is a natural product with effects similar to (-)-englerin A. Like (-)-englerin A the effects of tonantzitlolone appear to mediated by activation of cation flux via TRPC ion channels, principally the TRPC1/4/5 channel subtypes [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
Tonantzitlolone activates TRPC4-TRPC1 concatemers with an EC50 of 140 nM, and TRPC5-TRPC1 concatemers with an EC50 of 61 nM [1]. |
Selectivity at ion channels | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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