FzM1.8   Click here for help

GtoPdb Ligand ID: 10321

Compound class: Synthetic organic
Comment: FzM1.8 is a small-molecule allosteric agonist of FZD4 and activates the WNT/β-catenin pathway [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 5
Topological polar surface area 98.66
Molecular weight 322.1
XLogP 2.96
No. Lipinski's rules broken 0
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Canonical SMILES O=C(Nc1ccc2c(c1)cccc2)Nc1cc(O)cc(c1)C(=O)O
Isomeric SMILES O=C(Nc1ccc2c(c1)cccc2)Nc1cc(O)cc(c1)C(=O)O
InChI InChI=1S/C18H14N2O4/c21-16-9-13(17(22)23)8-15(10-16)20-18(24)19-14-6-5-11-3-1-2-4-12(11)7-14/h1-10,21H,(H,22,23)(H2,19,20,24)
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
FZD4 Hs Allosteric modulator Positive 6.4 pEC50 - 2
pEC50 6.4 [2]
Description: In a TCF/LEF reporter assay with WRE-GFP constructs.
FZD4 Hs Allosteric modulator Negative 5.5 – 7.8 pIC50 - 1
pIC50 5.5 – 7.8 [1]
Description: In TCF/LEF reporter assays with WRE-GFP constructs