namilumab

Ligand id: 10370

Name: namilumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Namilumab does not bind to either of the other colony-stimulating factors (G-CSF or M-CSF) [2]. It potently neutralises recombinant human GM-CSF produced in E. coli and yeast expression systems, and endogenous GM-CSF from human bronchial epithelial cells. It also binds and neutralises macaque GM-CSF.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF Hs Antibody Binding 10.3 pKd - 2
pKd 10.3 (Kd 4.6x10-11 M) [2]