namilumab   Click here for help

GtoPdb Ligand ID: 10370

Synonyms: AMG203 [5] | MT203
Immunopharmacology Ligand
Compound class: Antibody
Comment: Namilumab (AMG203, MT203) is an IgG1κ anti-macrophage colony-stimulating factor (GM-CSF; CSF2) monoclonal antibody [2]. It is being developed by Micromet and Nycomed for the treatment of autoimmune and chronic inflammatory diseases.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB entry.
Bioactivity Comments
Namilumab does not bind to either of the other colony-stimulating factors (G-CSF or M-CSF) [2]. It potently neutralises recombinant human GM-CSF produced in E. coli and yeast expression systems, and endogenous GM-CSF from human bronchial epithelial cells. It also binds and neutralises macaque GM-CSF.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
GM-CSF Primary target of this compound Hs Antibody Binding 10.3 pKd - 2
pKd 10.3 (Kd 4.6x10-11 M) [2]