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Compound class: Synthetic organic
Comment: MK-4815 is a small molecule with promising antimalarial activity .
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
|The interaction table below provides data from an evaluation of the antimalarial (asexual blood stage) activity of MK-4815, using a panel of P. falciparum strains, with the drug exhibiting efficacy against drug resistant strains. Further in vitro experiments indicate that MK-4815 accumulates in erythrocytes infected with the later developmental forms of the asexual blood stage parasite and that it is also most effective against these forms . In addition, the compound demonstrated good oral activity when tested in a P. berghei mouse model of acute malaria .|
|Whole organism assay data|
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