Synonyms: compound 39 [PMID: 31497959]
Compound class:
Synthetic organic
Comment: GSK2603566A is a pan αv integrin antagonist [1]. It is orally bioavailable and exhibits anti-fibrotic activity. GSK2603566A was tested as the racemic mixture of enantiomers.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
GSK2603566A inhibits αvβ6-mediated cell adhesion in vitro with a pIC50 of 6.9 [1]. IC50s for inhibtion of probe binding in a fluorescence polarisation assay are: 4 nM (αvβ3 and αvβ5), 16 nM (αvβ6) and 40 nM (αvβ8). |
Selectivity at catalytic receptors | ||||||||||||||||||||||||||||||||||
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