Synonyms: cannabidiolic acid methyl ester | CBDA-ME | HU580
Compound class:
Synthetic organic
Comment: HU-580 (cannabidiolic acid methyl ester; CBDA-ME) is a stable synthetic analogue of the naturally occurring phytocannabinoid, cannabidiolic acid (CBDA ) [1]. HU-580 has been shown to enhance maximal agonist activation of 5-HT1A receptors in a rat model, and produces anti-nausea and anti-anxiety effects which align with the biological profile reported for CBDA. The compound has efficacy in a rat model of peripheral neuropathic pain when administered at an early stage post-sciatic nerve surgery [2]. Interestingly this effect is only observed in male rats, indicating potential sexual dimorphism in this response.
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Bioactivity Comments |
HU-580 has no intrinsic 5‐HT1A receptor agonist or inverse agonist activity and it does not alter the mean EC50 for the 5‐HT1A receptor/8‐OH‐DPAT interaction [1]. CBDA (at 0.1 nM) increases the mean Emax value for 8‐OH‐DPAT-induced stimulation of [35S]‐GTPγS binding to 5‐HT1A receptor to 115% of control. At the same concentration HU-580 increases the Emax to 127% of control. |