ianalumab   Click here for help

GtoPdb Ligand ID: 10656

Synonyms: VAY-736 | VAY736
Immunopharmacology Ligand
Compound class: Antibody
Comment: Ianalumab (VAY736) is an investigtional anti-BAFF receptor (TNFRSF13C) monoclonal antibody (mAb) from Novartis. BLAST analysis of peptide sequences from its INN record reveal identical matches with peptide sequences claimed in Novartis patent WO2010007082A1 [2]. The sequence matches suggest that mAb MORO7347 identified in the patent could be VAY736.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
BAFF receptor Hs Antibody Antagonist 10.7 pIC50 - 2
pIC50 10.7 (IC50 1.9x10-11 M) [2]
Description: Inhibition of BAFFR-BLyS binding by the whole Ig mAb.