UCSF7447

Ligand id: 10666

Name: UCSF7447

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 53.6
Molecular weight 361.99
XLogP 5.78
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Bioactivity Comments
When administered at dusk, UCSF7447 advanced the phase of the circadian clock, in a MT1 receptor-dependent manner, in mice [1].
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
MT1 receptor Hs Agonist Inverse agonist 7.3 pEC50 - 1
pEC50 7.3 (EC50 4.786x10-8 M) [1]
MT2 receptor Hs Agonist Inverse agonist 6.0 pEC50 - 1
pEC50 6.0 (EC50 1.024x10-6 M) [1]