Synonyms: KRP-AM1977
Compound class:
Synthetic organic
Comment: Lascufloxacin (KRP-AM1977Y) is an investigational intravenous fluoroquinolone antiobiotic that was developed for lower respiratory tract infections [1]. It is effective against both aerobic and anaerobic bacteria, and is highly distributed in the lung.
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Bioactivity Comments |
The MIC for antibacterial activity against 100 strains of MRSA is 0.03-2 μg/ml in vitro [1]. Lascufloxacin is highly selectivity for bacterial topoisomerases, and has little activity against human topoisomerase II. |