Compound class:
Natural product or derivative
Comment: Napsamycin D and napsamycin C are uridylpeptide antibacterials, sharing a common structural scaffold with the mureidomycins and pacidamycins. Originally isolated from Streptomyces sp. HIL Y-82,11372, napsamycins have potent activity against Pseudomonas species but not against other Gram-negative or Gram-positive bacteria [1].
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Bioactivity Comments |
Napsamycin D activity is specifically against Pseudomonas strains. The MIC for antimicrobial activity is 6.25 μg/ml for Pseudomonas aeruginosa M35 and 50 μg/ml for Pseudomonas fluorescens [1]. The same study reported that napsamycin D exhibits very poor activity against other Gram-negative and Gram-positive bacteria. |