Synonyms: NSC-23766 | NSC23766
Compound class:
Synthetic organic
Comment: An inhibitor of the signalling G-protein known as Rac 1 (Ras-related C3 botulinum toxin substrate 1), where it acts as a selective inhibitor of Rac1-GEF interaction. Marketed as NSC 23766 trihydrochloride.
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Bioactivity Comments |
Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 μM) without affecting Cdc42 or RhoA activation. |
Selectivity at ligand targets | ||||||||||||||||||||||||||||||||||
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