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Compound class: Synthetic organic
Comment: ADG-207 is an acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor .
|In vivo (in mice), ADG-207 impairs spatial object memory but does not alter levels of locomotion, coordination, body weight, or anxiety compared to controls . At the molecular level, ADG-207 reduced ACSS2-dependent incorporation of acetate derived from hepatic alcohol metabolism into histone acetylation in brain tissue from treated mice.|
|Selectivity at enzymes|
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