cannabichromene   Click here for help

GtoPdb Ligand ID: 11093

Synonyms: (+/-)-Cannabichromene | cannabichrome | CBC
Comment: Cannabichromene (CBC) is a phytocannabinoid.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 29.46
Molecular weight 314.22
XLogP 6.78
No. Lipinski's rules broken 1
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Canonical SMILES CCCCCc1cc2OC(C)(CCC=C(C)C)C=Cc2c(c1)O
Isomeric SMILES CCCCCc1cc2OC(C)(CCC=C(C)C)C=Cc2c(c1)O
InChI InChI=1S/C21H30O2/c1-5-6-7-10-17-14-19(22)18-11-13-21(4,23-20(18)15-17)12-8-9-16(2)3/h9,11,13-15,22H,5-8,10,12H2,1-4H3
Bioactivity Comments
CBC is not active at CB1 or CB2 receptors, and is thought to exert its effects via modulation of TRP ion channel activity [2].
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
TRPA1 Rn Activator Agonist 7.2 pEC50 - 1
pEC50 7.2 (EC50 6x10-8 M) [1]
Description: Measuring increase in intracellular calcium influx in HEK293 cells expressing rat TRPA1.