Compound class:
Synthetic organic
Comment: Permanently charged sodium channel blocker. This entry shows the compound without the associated bromide ion [1]. In human clinical trials as a topical gel for the treatment of pruritus (itch) associated with atopic dermatitis.
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Bioactivity Comments |
Because of its permanent positive charge, ASN008 cannot gain access to the interior of the cell by passively permeating through the cell membrane. However, ASN008 is believed to gain access to the interior of the cell to block the sodium channels, by passage through the large gated pores present in TRPA1 and TRPV1 channels [1]. |