Synonyms: compound 2f [PMID: 15857140] | HDAC-IN-1 | MC-1568
Compound class:
Synthetic organic
Comment: MC1568 is an inhibitor of class IIa (HDAC4, HDAC5, HDAC6, HDAC7 and HDAC9) and IIb (HDAC6 and HDAC10) histone deacetylases (HDACs) [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
MC1568 inhibits immunoprecipitated human HDAC4 (from cell lystates from human ZR-75.1 breast cancer cells) by 55% (5 μM), but is inactive vs. immunoprecipitated human HDAC1. Unsurprisingly, it has no effect on HDAC1-mediated apoptosis, granulocytic differentiation, and cell cycle arrest in U937 acute myeloid leukemia (AML) cells [1]. |