Synonyms: ORM10962
Compound class:
Synthetic organic
Comment: ORM-10962 is a selective inhibitor of the SCL8 (NCX) Na+/Ca2+ exchangers [1]. It blocks both inward and outward NCX currents. ORM-10962 has been used in vivo to demonstrate that NCX blockade may contribute to the prevention of delayed afterdepolarization-based arrhythmogenesis.
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Bioactivity Comments |
ORM-10962 blocks the INCX current in isolated canine myoctytes with an EC50 of 55 nM for the inward current and 67 nM for the outward current [1]. |
Ligand mentioned in the following text fields |
SLC8 family of sodium/calcium exchangers comments |