Synonyms: example 18 [WO2013166396A2]
Compound class:
Synthetic organic
Comment: The chemical structure that was submitted to the WHO for the INN ipivivint leads to Samumed's patent WO2013166396A2 , as compound 18 therein [1]. Ipivivint is defined as a Wnt pathway inhibitor. Samumed have a lead candidate called SM08502 in their pipeline. SM08502 is reported to decrease Wnt signalling in tumour cells via inhibition of CDC-like kinase (CLK) activity in an article from Samumed scientists [2]. We speculate that ipivivint might be SM08502, but as of August 2020 there is no formal disclosure of SM08502's chemical structure. SM08502 is being investigated in a Phase 1 clinical trial in patients with advanced solid tumours (NCT03355066).
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Bioactivity Comments |
Compound 18 inhibits Wnt signalling in reporter-based assays in human bronchial epithelial NL-20 cells with an IC50 of 440 nM, and in human colon cancer SW480 cells with an IC50 of 13 nM [1]. |