casirivimab   Click here for help

GtoPdb Ligand ID: 11327

Synonyms: REGN-10933 | Ronapreve® (imdevimab + casirivimab)
Approved drug
casirivimab is an approved drug (Japan, EMA and UK MHRA (2021))
Compound class: Antibody
Comment: Casirivimab (REGN10933) is a fully human monoclonal antibody against the surface spike protein of SARS-CoV-2 [1-2]. It is a virus neutralising mAb that was developed by Regeneron.
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Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CoV Spike glycoprotein SARS-CoV-2 Antibody Binding 10.2 pIC50 - 2
pIC50 10.2 (IC50 6.9x10-11 M) [2]
Description: IC50 for ability of mAb to compete with spike protein for binding to hACE2.