casirivimab   Click here for help

GtoPdb Ligand ID: 11327

Synonyms: REGN-10933 | Ronapreve® (imdevimab + casirivimab)
Approved drug
casirivimab is an approved drug (Japan, EMA and UK MHRA (2021))
Compound class: Antibody
Comment: Casirivimab (REGN10933) is a fully human monoclonal antibody against the surface spike protein of SARS-CoV-2 [1-2]. It is a virus neutralising mAb that was developed by Regeneron.
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1. Baum A, Ajithdoss D, Copin R, Zhou A, Lanza K, Negron N, Ni M, Wei Y, Mohammadi K, Musser B et al.. (2020)
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
Science, 370 (6520): 1110-1115. [PMID:33037066]
2. Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K et al.. (2020)
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Science, 369 (6506): 1010-1014. [PMID:32540901]
3. Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, Musser BJ, Soo Y, Rofail D, Im J et al.. (2021)
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.
N Engl J Med, 384 (3): 238-251. [PMID:33332778]