casirivimab   Click here for help

GtoPdb Ligand ID: 11327

Synonyms: REGN-10933 | Ronapreve® (imdevimab + casirivimab)
Approved drug
casirivimab is an approved drug (Japan, EMA and UK MHRA (2021))
Compound class: Antibody
Comment: Casirivimab (REGN10933) is a fully human monoclonal antibody against the surface spike protein of SARS-CoV-2 [1-2]. It is a virus neutralising mAb that was developed by Regeneron.
Click here for help
References
1. Baum A, Ajithdoss D, Copin R, Zhou A, Lanza K, Negron N, Ni M, Wei Y, Mohammadi K, Musser B et al.. (2020)
REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters.
Science, 370 (6520): 1110-1115. [PMID:33037066]
2. Hansen J, Baum A, Pascal KE, Russo V, Giordano S, Wloga E, Fulton BO, Yan Y, Koon K, Patel K et al.. (2020)
Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail.
Science, 369 (6506): 1010-1014. [PMID:32540901]
3. Weinreich DM, Sivapalasingam S, Norton T, Ali S, Gao H, Bhore R, Musser BJ, Soo Y, Rofail D, Im J et al.. (2021)
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.
N Engl J Med, 384 (3): 238-251. [PMID:33332778]