Synonyms: ITZ | R-51211 | R51211 | Sporanox®
itraconazole is an approved drug (FDA (1992), UK (1989))
Compound class:
Synthetic organic
Comment: Itraconazole is an antimycotic drug. It inhibits fungal cytochrome P450 enzymes. It has been reported to exhibit antiviral activity towards SARS-CoV-2 (in VERO-E6 cells), potentially via inhibition of the virus' main protease (M-Pro, 3CL-Pro).
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Bioactivity Comments |
A repurposing screen found that itraconazole inhibited the activity of SARS-CoV-2 3CL-Pro by ~12% in vitro. |