Bioactivity Comments

A meeting abstract indicates that dostarlimab has high affinity for both human and cynomolgus monkey PD-1, but does not cross-react with the mouse orthologue, and that it inhibits the interaction of both PD-L1 and PD-L2 with PD-1.

Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference programmed cell death 1 (CD279) Hs Antibody Binding - - - 1 ⤷ [1]