olokizumab   Click here for help

GtoPdb Ligand ID: 11601

Synonyms: CDP 6038 | CDP-6038 | CDP6038
Compound class: Antibody
Comment: Olokizumab (CDP 6038) is a clinical stage anti-IL-6 monoclonal antibody [3], that was designed for potential to treat autoimmune diseases. The antibody blocks assembly of the hexameric IL-6/IL-6 α-receptor/gp130 (IL6ST) complex that is required for signal transduction.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-6 Hs Antibody Binding 11.0 pKd - 3
⤷ pKd 11.0 (Kd 1x10-11 M) [3]
Description: Binding affinity determined in a Biacore SPR assay with immobilised antibody and hIL-6 in the solution phase.