Synonyms: CVM-1118 | TRX 818 | TRX-818
Compound class:
Synthetic organic
Comment: Foslinanib (CVM-1118) is an orally bioavailable protein kinase inhibitor with antiangiogenic and antineoplastic activities [1].
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Bioactivity Comments |
CVM-1118 has a short elimination half-life. It was tested for anti-proliferative activity in human cancer cell lines [1]. Signalling pathways analysis suggests that CVM-1118 acts by modulating multiple pathways: repression of VEGF and Notch, activation of caspase cleavage and apoptosis, and activation of genes that initiate cell death and/or cause growth arrest, |