Synonyms: Example 9 [WO2013107283A1]
Compound class:
Synthetic organic
Comment: We obtained the chemical structure for tunlametinib from WHO Proposed list 125 (July 2021). This mapped to PubChem CID 71621329. The chemical structure is claimed in Tianjin Binjiang Pharma's patent WO2013107283A1 for activity as a MEK inhibitor with potential to treat cancers and inflammation [1].
|
|
Bioactivity Comments |
Tunlametinib (example 9) inhibits proliferation of HT29 and A375 cancer cell lines in vitro (IC50 ≤1 nM), and exhibits anti-tumour efficacy in an HT29 and COLO205 tumour xenograft models. No data for inhibition of MEK enzymatic activity is provided in WO2013107283A1 [1]. |