Z-AVLD-FMK   Click here for help

GtoPdb Ligand ID: 11712

Comment: Z-AVLD-FMK is a fluoromethylketone (FMK) modified 4 amino acid peptide, that has subnanomolar potency against SARS-CoV-2 3CL-like protease (Mpro) [1]. It is a peptidomimetic of the Mpro substrate sequence within the viral polyprotein.
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Bioactivity Comments
Z-AVLD-FMK inhibits SARS-CoV-2 growth in Vero E6 cells with an EC50 of 66 μM [1].
Selectivity at other protein targets
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
CoV 3C-like (main) protease SARS-CoV-2 Inhibitor Inhibition 9.1 pIC50 - 1
pIC50 9.1 (IC50 8x10-10 M) [1]
Description: Inhibition in a FRET-based enzyme activity assay