Z-AVLD-FMK   Click here for help

GtoPdb Ligand ID: 11712

Comment: Z-AVLD-FMK is a fluoromethylketone (FMK) modified 4 amino acid peptide, that has subnanomolar potency against SARS-CoV-2 3CL-like protease (Mpro) [1]. It is a peptidomimetic of the Mpro substrate sequence within the viral polyprotein.
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1. Milligan JC, Zeisner TU, Papageorgiou G, Joshi D, Soudy C, Ulferts R, Wu M, Lim CT, Tan KW, Weissmann F et al.. (2021)
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Biochem J, 478 (13): 2499-2515. [PMID:34198327]